Use of vaccinia rabies recombinant for oral vaccination of wildlife
Identifieur interne : 001487 ( Main/Exploration ); précédent : 001486; suivant : 001488Use of vaccinia rabies recombinant for oral vaccination of wildlife
Auteurs : P. Desmettre [France] ; B. Languet [France] ; G. Chappuis [France] ; B. Brochier [Belgique] ; I. Thomas [Belgique] ; J.-P. Lecocq [France] ; M.-P. Kieny [France] ; J. Blancou [France] ; M. Aubert [France] ; M. Artois [France, Belgique] ; P.-P. Pastoret [Belgique]Source :
- Veterinary Microbiology [ 0378-1135 ] ; 1990.
Abstract
A vaccinia rabies recombinant virus was contructed and shown to induce the synthesis of rabies virus glycoprotein in infected cells and to induce rabies virus neutralizing antibodies and protection in susceptible animals. Active when orally administered, this recombinant is a good candidate for the development of vaccines for wild animal rabies vectors. This recombinant was found stable, safe for target and non-target animal species, and protective for most of the rabies vectors. After extensive experimental studies conducted under controlled conditions, it as used in limited field trials and in an extensive open field trial. The preliminary results confirmed its basic properties and potential for rabies eradication.
Url:
DOI: 10.1016/0378-1135(90)90153-M
Affiliations:
- Belgique, France
- Auvergne-Rhône-Alpes, Grand Est, Lorraine (région), Province de Liège, Rhône-Alpes, Région wallonne
- Liège, Lyon, Malzéville
- Université de Liège
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Active when orally administered, this recombinant is a good candidate for the development of vaccines for wild animal rabies vectors. This recombinant was found stable, safe for target and non-target animal species, and protective for most of the rabies vectors. After extensive experimental studies conducted under controlled conditions, it as used in limited field trials and in an extensive open field trial. The preliminary results confirmed its basic properties and potential for rabies eradication.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Grand Est</li><li>Lorraine (région)</li><li>Province de Liège</li><li>Rhône-Alpes</li><li>Région wallonne</li></region><settlement><li>Liège</li><li>Lyon</li><li>Malzéville</li></settlement><orgName><li>Université de Liège</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Desmettre, P" sort="Desmettre, P" uniqKey="Desmettre P" first="P." last="Desmettre">P. Desmettre</name></region><name sortKey="Artois, M" sort="Artois, M" uniqKey="Artois M" first="M." last="Artois">M. Artois</name><name sortKey="Artois, M" sort="Artois, M" uniqKey="Artois M" first="M." last="Artois">M. Artois</name><name sortKey="Artois, M" sort="Artois, M" uniqKey="Artois M" first="M." last="Artois">M. Artois</name><name sortKey="Aubert, M" sort="Aubert, M" uniqKey="Aubert M" first="M." last="Aubert">M. Aubert</name><name sortKey="Blancou, J" sort="Blancou, J" uniqKey="Blancou J" first="J." last="Blancou">J. Blancou</name><name sortKey="Chappuis, G" sort="Chappuis, G" uniqKey="Chappuis G" first="G." last="Chappuis">G. Chappuis</name><name sortKey="Kieny, M P" sort="Kieny, M P" uniqKey="Kieny M" first="M.-P." last="Kieny">M.-P. Kieny</name><name sortKey="Languet, B" sort="Languet, B" uniqKey="Languet B" first="B." last="Languet">B. Languet</name><name sortKey="Lecocq, J P" sort="Lecocq, J P" uniqKey="Lecocq J" first="J.-P." last="Lecocq">J.-P. Lecocq</name></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Brochier, B" sort="Brochier, B" uniqKey="Brochier B" first="B." last="Brochier">B. Brochier</name></region><name sortKey="Artois, M" sort="Artois, M" uniqKey="Artois M" first="M." last="Artois">M. Artois</name><name sortKey="Pastoret, P P" sort="Pastoret, P P" uniqKey="Pastoret P" first="P.-P." last="Pastoret">P.-P. Pastoret</name><name sortKey="Thomas, I" sort="Thomas, I" uniqKey="Thomas I" first="I." last="Thomas">I. Thomas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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